This study investigates the leishmanicidal activity of five species of plants used in folk medicine in endemic areas of the state of\nAlagoas, Brazil. Data were collected in the cities of Colonia Leopoldina, Novo Lino, and UniÃ?Å?ao dos Palmares, Alagoas state, from\npatients with cutaneous leishmaniasis (Leishmania amazonensis) who use medicinal plants to treat this disease. Plants extracts\nwere tested at a concentration of 1ââ?¬â??100 ????g/mL in all experiments, except in an assay to evaluate activity against amastigotes, when\n10 ????g/mL was used. All plants extracts did not show deleterious activity to the host cell evidenced by LDH assay at 100, 10, and\n1 ????g/mL after 48 h of incubation. The plants extracts Hyptis pectinata (L.) Poit, Aloe vera L., Ruta graveolens L., Pfaffia glomerata\n(Spreng.) Pedersen, and Chenopodium ambrosioides L. exhibited direct activity against extracellular forms at 100 ????g/mL; these\nextracts inhibited growth by 81.9%, 82.9%, 74.4%, 88.7%, and 87.4%, respectively, when compared with promastigotes. The plants\nextracts H. pectinata, A. vera, and R. graveolens also significantly diminished the number of amastigotes at 10 ????g/mL, inhibiting\ngrowth by 85.0%, 40.4%, 94.2%, and 97.4%, respectively, when compared with control. Based on these data, we conclude that the\nfive plants exhibited considerable leishmanicidal activity.
Loading....